Applications of the genO‑hTFRC/hFcγR mouse model

Useful applications for researchers working on different biomedical fields, such as immuno-oncology, neuroscience, and autoimmunity:

  • Improve the biodistribution of therapeutic agents with an Fc competent region aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (CD71, TFCR) binding and test their efficacy:
    • Assess the efficacy of immunotherapies in cancers that overexpress TFRC
    • Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
  • Allow for ranking of antibodies by accessing different binding affinities
  • Gain insight into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefit
  • Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics

Features

  • Physiological regulation and expression pattern of human TFRC and hFcγR
  • Lack of expression of the murine target genes (murine TFRC and murine FcγRs)
  • Functional Fcγ receptors enable the assessment of Fc-mediated effector functions
  • Fully functional mouse immune system

Clients

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑hTFRC/hFcγR

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