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Applications of the genO‑hTFRC/hFcγR mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, neuroscience, and autoimmunity:
- Improve the biodistribution of therapeutic agents with an Fc competent region aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (CD71, TFCR) binding and test their efficacy:
- Assess the efficacy of immunotherapies in cancers that overexpress TFRC
- Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
- Allow for ranking of antibodies by accessing different binding affinities
- Gain insight into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefit
- Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics
Features
- Physiological regulation and expression pattern of human TFRC and hFcγR
- Lack of expression of the murine target genes (murine TFRC and murine FcγRs)
- Functional Fcγ receptors enable the assessment of Fc-mediated effector functions
- Fully functional mouse immune system
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