Target

Gene symbol :  
Brk1
NCBI gene ID :  
101314
Gene full name :  
BRICK1, SCAR/WAVE complex subunit
Synonym :  
HSPC300, C3orf10

Protein function

Protein name :  
BRK1
Regulates actin cytoskeleton and lamellipodia formation via the WAVE complex.

Expected phenotype

Defects in cell migration and cytoskeletal dynamics

Human disease relevance

Linked to immune cell motility and cancer cell invasion

Model applications

Actin regulation, WAVE complex, cell motility

Keywords:

Cytoskeleton, WAVE, Actin remodeling

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Brk1

conditional Knockout mouse

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