Sirt1 conditional Knockout mouse

Target

Gene symbol :

Sirt1

NCBI gene ID :

93759

Gene full name :

Sirtuin 1

Synonym :

Sir2, Sir2alpha, SIR2L1

Protein function

Protein name :

NAD-dependent deacetylase SIRT1

Regulates lifespan, metabolism, inflammation, and gene expression via deacetylation

Expected phenotype

Knockouts display metabolic syndrome, inflammation, reduced lifespan; overexpression extends lifespan in brain-specific studies

Human disease relevance

Associated with aging, diabetes, neurodegeneration, cancer

Model applications

Widely used in aging, metabolism, and chronic disease models

Keywords:

Deacetylase, Metabolism, Aging, Cancer, NAD-dependent

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Sirt1

conditional Knockout mouse

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