This study investigates changes in cannabinoid receptor 1 (CB1) expression within glial cells in the subiculum of a mouse model of Alzheimer's disease (AD). Utilizing immuno-electron microscopy, researchers observed increased CB1 receptor expression in reactive microglia surrounding amyloid plaques, while astrocytic CB1 expression remained constant but showed increased labeling corresponding to astrocyte perimeter expansion. These findings suggest a role for CB1 receptors in glial responses to AD pathology.
Enhanced CB1 receptor expression in reactive microglia and altered astrocytic CB1 labeling patterns in the subiculum of AD model mice indicate a potential involvement of CB1 receptors in glial-mediated neuroinflammatory responses in Alzheimer's disease.
5xFAD/CB2-EGFP(f/f) transgenic mouse model, combining the 5xFAD Alzheimer's disease model with a CB2-EGFP reporter to study glial CB1 receptor expression changes.
Alzheimer's disease, Neuroinflammation, Glial cells, Cannabinoid receptors, Subiculum
Transgenic mouse model, 5xFAD, CB2-EGFP reporter, Immuno-electron microscopy, Glial cell analysis
From model design to experimental results
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