This study evaluates the role of Fc-dependent effector functions in the protective activity of anti-circumsporozoite protein (CSP) antibodies against malaria. Mice expressing human Fcγ receptors were used to assess the relevance of Fc engagement in vivo.
Fc-dependent functions, especially FcγR-mediated phagocytosis, are essential for optimal protection conferred by anti-CSP antibodies.
hFcγR humanized mouse model generated by genOway, expressing human Fc gamma receptors instead of mouse counterparts.
Infectious disease, Malaria, Vaccine evaluation, Antibody effector function
Humanized Knockin, FcγR, Antibody-dependent cellular cytotoxicity (ADCC), Phagocytosis assay
From model design to experimental results
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Models with certified health status from professional breeders in US and Europe
