An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Aina Karen Anthi
Oslo University Hospital
May 1, 2025
Nat Commun
https://pubmed.ncbi.nlm.nih.gov/40312392

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/40312392

Research summary

This study evaluates an intranasal subunit vaccine based on albumin-antigen fusion to induce systemic and mucosal immunity. Using the HSA/hFcRn mouse model, the vaccine elicited robust systemic IgG and mucosal IgA responses, providing protection against SARS-CoV-2 and influenza A virus. The model allowed precise evaluation of FcRn-mediated antibody transport and persistence.

Key outcome of the study

Albumin-based intranasal vaccination induced strong systemic and mucosal antibody responses and superior protection compared to standard mRNA and non-albumin nasal vaccines.

Model

Humanized double Knockin HSA/hFcRn mouse model developed by genOway, expressing human serum albumin and FcRn for accurate pharmacokinetic and immunogenicity studies.

TARGET:
SARS-CoV-2 spike protein, Influenza A hemagglutinin
Spike protein (S), Hemagglutinin (HA)

Keywords

Respiratory viruses, Intranasal vaccine, Mucosal immunity, SARS-CoV-2, Influenza, FcRn pharmacology

Technical specifications

Humanized Knockin model, HSA/hFcRn expression, Albumin fusion vaccine, Intranasal delivery

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genO‑hSA/hFcRn

Double humanized genO‑hSA/hFcRn mouse model as a cutting-edge platform for preclinical development of hSA and FcRn-oriented therapeutics.

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