Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies

Stefanutti E
Vir Biotechnology
July 23, 2025
Microbiol Spectr
https://pubmed.ncbi.nlm.nih.gov/40698943

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/40698943

Research summary

This study evaluates the role of Fc-dependent effector functions in the protective activity of anti-circumsporozoite protein (CSP) antibodies against malaria. Mice expressing human Fcγ receptors were used to assess the relevance of Fc engagement in vivo.

Key outcome of the study

Fc-dependent functions, especially FcγR-mediated phagocytosis, are essential for optimal protection conferred by anti-CSP antibodies.

Model

hFcγR humanized mouse model generated by genOway, expressing human Fc gamma receptors instead of mouse counterparts.

TARGET:
Fcγr
Synonyms:
Fc gamma receptor

Keywords

Infectious disease, Malaria, Vaccine evaluation, Antibody effector function

Technical specifications

Humanized Knockin, FcγR, Antibody-dependent cellular cytotoxicity (ADCC), Phagocytosis assay

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