This study investigates the in vivo biodistribution and therapeutic potential of polymer-coated DNA origami nanostructures, particularly in modulating TNF-α-driven inflammatory responses. The research evaluates how polymer-DNA conjugates influence nanostructure stability, tissue distribution, and their potential anti-inflammatory effects.
DNA origami nanostructures functionalized with anti-TNF-α aptamers exhibited significant anti-inflammatory effects in a delayed-type hypersensitivity model using humanized TNF-α mice. The study demonstrated improved biodistribution and pharmacokinetics of the polymer-conjugated DNA nanostructures.
Humanized TNF-α Knockin mouse model developed by genOway, in which the murine Tnf gene is replaced by its human counterpart. This model allows for the evaluation of human-specific TNF-α interactions in inflammation-related studies.
Inflammation, TNF-α signaling, Nanomedicine, Drug delivery, DNA nanotechnology, Autoimmune diseases
Humanized Knockin mouse model, TNF-α, DNA origami, Polymer conjugation, In vivo biodistribution, Pharmacokinetics
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
