This study investigates the role of BDNF expression in serotonergic neurons on stress resilience and hippocampal neurogenesis. Using a mouse model with Rosa26-inserted mouse Bdnf under serotonergic control, researchers showed enhanced neurogenesis and behavioral resilience following stress.
Serotonergic BDNF expression improves adult hippocampal neurogenesis and stress coping, highlighting BDNF as a neuromodulatory target in mood and neuroplasticity.
Rosa26 Knockin mouse model overexpressing mouse Bdnf under SERT-Cre control, developed to study serotonergic neuron-specific neurotrophic signaling.
Neurogenesis, Stress resilience, Depression, Serotonergic system, BDNF
Knockin, Rosa26 locus, SERT-Cre, Mouse Bdnf, Cell-type specific overexpression
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
