This study investigates the role of BDNF expression in serotonergic neurons on stress resilience and hippocampal neurogenesis. Using a mouse model with Rosa26-inserted mouse Bdnf under serotonergic control, researchers showed enhanced neurogenesis and behavioral resilience following stress.
Serotonergic BDNF expression improves adult hippocampal neurogenesis and stress coping, highlighting BDNF as a neuromodulatory target in mood and neuroplasticity.
Rosa26 Knockin mouse model overexpressing mouse Bdnf under SERT-Cre control, developed to study serotonergic neuron-specific neurotrophic signaling.
Neurogenesis, Stress resilience, Depression, Serotonergic system, BDNF
Knockin, Rosa26 locus, SERT-Cre, Mouse Bdnf, Cell-type specific overexpression
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