This study investigates the role of brain-derived neurotrophic factor (BDNF) neurons in the brainstem as downstream effectors of GFRAL and GLP-1 receptor (GLP1R) signaling pathways. The research explores how these pathways interact to regulate energy balance and feeding behavior.
Gfral-Cre Model: Activation of GFRAL-expressing neurons influenced feeding behavior, indicating their role in appetite regulation. Prlh-Cre Model: PRLH-expressing neurons were found to act downstream of GFRAL/GLP1R signaling pathways, contributing to the modulation of feeding behavior.
1. Gfral-Cre Knockin Mouse Model: A Cre-driver line with the Gfral gene promoter driving Cre recombinase expression, enabling targeted gene manipulation in GFRAL-expressing neurons. 2. Prlh-Cre Knockin Mouse Model: A Cre-driver line with the Prlh gene promoter driving Cre recombinase expression, allowing for specific gene manipulation in PRLH-expressing neurons.
Neuroscience, Appetite regulation, Energy homeostasis, Neuroendocrinology, Feeding behavior
Cre-loxP system, Knockin mouse models, Neuron-specific gene manipulation, Conditional gene expression, Neurocircuitry analysis, IRES
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
