This study investigates the role of interphotoreceptor retinoid-binding protein (IRBP) in retinal health and eye development. By creating conditional Knockout models, the research aims to elucidate how the absence of IRBP affects retinal degeneration and the development of myopia, potentially through distinct mechanisms.
The conditional Knockout of IRBP resulted in retinal degeneration and myopic shifts, indicating that IRBP is crucial for maintaining retinal integrity and proper eye development. The findings suggest that the mechanisms leading to retinal degeneration and myopia due to IRBP deficiency are independent of each other.
The study utilized a conditional Knockout mouse model developed in collaboration with genOway. This model features loxP sites flanking critical exons of the Irbp gene, allowing for tissue-specific deletion of IRBP when crossed with mice expressing Cre recombinase under specific promoters. This design enables the study of IRBP's role in particular retinal cell types and developmental stages.
Retinal degeneration, Myopia, Ophthalmic genetics, Visual disorders, Retinoid cycle
Conditional Knockout, LoxP/Cre system, Tissue-specific gene deletion, Retinal cell targeting, Genetic model
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
