This study examines the impact of PCPE-1 deficiency on cardiac collagen content and heart function under basal conditions using PCPE-1 Knockout mice.
PCPE-1 deficiency did not significantly alter cardiac collagen content or function under normal conditions. A slight decrease in ejection fraction was observed in male Knockout mice, with no major change in wound healing or collagen-related gene expression.
PCPE-1 Knockout mouse model developed by genOway, based on embryonic stem cells obtained from the EUCOMM repository, allowing targeted inactivation of the Pcolce gene.
Cardiac fibrosis, Heart function, Collagen regulation, Procollagen processing
Knockout mouse model, EUCOMM-derived ES cells, Targeted gene inactivation, Echocardiography, Collagen quantification
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
