This study explores the development of a humanized rat model by engrafting human CD34+ hematopoietic stem cells (HSCs) into immunodeficient rats. The research aims to establish a robust platform for studying human immune responses and diseases within a rat model, which offers advantages over existing mouse models due to its larger size and physiological similarities to humans.
The humanized rat model demonstrated successful engraftment of human CD34+ cells, leading to the development of functional human immune cells. This model provides a valuable tool for preclinical research, including the evaluation of immunotherapies and the study of human-specific pathogens.
The study utilized an immunodeficient rat model developed in collaboration with genOway. These rats were genetically engineered to lack functional T, B, and NK cells, creating a permissive environment for the engraftment and development of a human immune system. The model allows for the differentiation and maturation of human immune cells, enabling the study of human-specific immune functions and disease processes.
Immunology, Humanized animal models, Hematopoietic stem cell transplantation, Preclinical research, Immunotherapy evaluation
Immunodeficient rat, Human CD34+ cell engraftment, T cell deficiency, B cell deficiency, NK cell deficiency, Human immune system development
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
