This study reveals that gonadotrophs in the pituitary gland originate from two distinct populations: embryonic progenitors and early postnatal pituitary stem cells. Using lineage tracing in mice, researchers demonstrated that the majority of adult gonadotrophs are derived from stem cells activated after birth, independent of gonadal signals or GnRH stimulation.
Identification of a dual origin of gonadotrophs, with most arising postnatally from stem cells; this challenges previous understanding and has implications for reproductive health disorders.
Double and triple transgenic mouse models combining Sox2^2A-rtTA/+ and TetO-Cre alleles for doxycycline-inducible Cre expression in Sox2+ stem cells, crossed with Rosa26^ReYFP/+ Cre-reporter mice. Lef1^CreERT2/+ mice with tamoxifen-inducible Cre expression were also used for complementary lineage tracing.
Reproductive biology, Pituitary development, Stem cell differentiation, Puberty disorders
Inducible Cre-loxP system, Lineage tracing, Rosa26 reporter, Stem cell activation, Doxycycline-inducible Cre, Tamoxifen induction
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