This study examines the effect of imiquimod (IMQ) on skin inflammation in humanized BRGSF mice boosted with human Flt3L. Although skin inflammation and epidermal thickening occurred, the response was mainly mediated by murine immune cells, with limited human immune cell activation.
IMQ treatment induced skin inflammation characterized by epidermal thickening and immune cell infiltration. However, human immune cell activity remained limited, with the inflammatory response largely driven by the murine immune system.
BRGSF-HIS humanized mouse model developed by genOway, reconstituted with human CD34+ hematopoietic stem cells and boosted with human Flt3L to support human immune system engraftment.
Psoriasis, Skin inflammation, Humanized models, Innate immunity, Flt3L boosting
Humanized BRGSF-HIS mouse model, CD34+ HSC reconstitution, hFlt3L boost, IMQ topical treatment, Skin inflammation model
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
