This study investigates the impact of maternal α-casein deficiency on the lifespan and body composition of offspring. The research aims to understand how maternal nutrition, specifically the absence of α-casein in milk, influences the developmental programming and long-term health outcomes of the progeny.
Offspring nursed by α-casein-deficient mothers exhibited an extended lifespan and altered body composition, characterized by reduced adiposity. These findings suggest that maternal α-casein levels play a significant role in shaping the metabolic health and longevity of offspring.
The study utilized a genetically modified mouse model developed in collaboration with genOway. This model features a targeted deletion of the Csn1s1 gene, which encodes α-casein, resulting in its absence in maternal milk. This design allows researchers to assess the effects of α-casein deficiency during lactation on offspring development and health.
Developmental programming, Maternal nutrition, Lifespan extension, Metabolic health, Obesity prevention
Gene Knockout, Lactation deficiency model, Nutritional programming, Transgenic mouse, Milk protein alteration
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
