This study investigates the role of CTLA4-expressing T cells in resolving lung fibrosis. Using a humanized CTLA4 mouse model and treatment with ipilimumab, researchers observed reduced fibrosis, decreased senescent cell accumulation, and enhanced lung epithelial regeneration.
Reactivation of hCTLA4-expressing T cells via ipilimumab treatment promoted clearance of senescent cells, enhanced alveolar epithelial cell proliferation, and accelerated resolution of lung fibrosis.
Humanized CTLA4 (hCTLA4) Knockin mouse model developed by genOway, replacing the extracellular domain of murine CTLA4 with its human counterpart to enable preclinical evaluation of anti-hCTLA4 antibodies such as ipilimumab.
Lung fibrosis, CTLA4, Immunotherapy, T cell regulation, Senescence, Regenerative medicine
Humanized CTLA4 Knockin mouse model, Extracellular domain replacement, Ipilimumab testing, T cell functional assays, Fibrosis resolution model
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
