This study demonstrates that Netrin-1 (Ntn1) is essential for the survival of SHH-subtype medulloblastomas. Inhibiting Netrin-1 induces tumor cell apoptosis and improves survival in vivo.
Netrin-1 is required for tumor cell survival and represents a viable therapeutic target in SHH-subtype medulloblastoma.
Ntn1^flox/flox mouse model used to conditionally delete Netrin-1 in the brain and assess its role in SHH-medulloblastoma.
Medulloblastoma, Pediatric oncology, SHH signaling, Neuro-oncology
Conditional knockout, Cre-loxP, Brain-specific deletion, Tumor model, SHH pathway
From model design to experimental results
Featured in 600+ scientific articles
Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions
Generated with biopharma partners and in-house
and guaranteed freedom to operate
Models with certified health status from professional breeders in US and Europe
