This study demonstrates that Netrin-1 (Ntn1) is essential for the survival of SHH-subtype medulloblastomas. Inhibiting Netrin-1 induces tumor cell apoptosis and improves survival in vivo.
Netrin-1 is required for tumor cell survival and represents a viable therapeutic target in SHH-subtype medulloblastoma.
Ntn1^flox/flox mouse model used to conditionally delete Netrin-1 in the brain and assess its role in SHH-medulloblastoma.
Medulloblastoma, Pediatric oncology, SHH signaling, Neuro-oncology
Conditional knockout, Cre-loxP, Brain-specific deletion, Tumor model, SHH pathway
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
