This study demonstrates that Netrin-1 (Ntn1) is essential for the survival of SHH-subtype medulloblastomas. Inhibiting Netrin-1 induces tumor cell apoptosis and improves survival in vivo.
Netrin-1 is required for tumor cell survival and represents a viable therapeutic target in SHH-subtype medulloblastoma.
Netrin-1 IRES-tdTomato Knockin reporter mouse model developed by genOway; used to track and study Ntn1-expressing cells in SHH-driven medulloblastoma.
Medulloblastoma, Pediatric oncology, SHH signaling, Neuro-oncology
Conditional Knockout, Cre-loxP, Brain-specific deletion, Tumor model, SHH pathway
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
