Exploring tumor-immune interactions in genO‑BRGSF‑HIS mice: myeloid and lymphoid cell recruitment dynamics

November 20, 2025

Duration: 31 min

Content

▶️Functional human myeloid and lymphoid cells, including γδ T cells and NK develop in genO-BRGSF-HIS

▶️Recruitment of these cells into the tumor microenvironment is observed to be tumor type- and burden-dependent

▶️The model represents a platform for assessing the efficacy and mechanism of action of immunotherapies

Speaker

Fabiane Sônego, PhD in Immunology and Pharmacology, is the Director of Preclinical Models and Services at genOway. She has extensive expertise in in vivo models for immuno-oncology and inflammation and a proven track record of supporting researchers in advancing translational research and accelerating drug development.

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Exploring tumor-immune interactions in genO‑BRGSF‑HIS mice: myeloid and lymphoid cell recruitment dynamics

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genO-BRGSF-HIS

genO‑BRGSF‑HIS mice possess the most functional reconstituted human immune system currently on the market and are highly relevant for translational research.

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