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Catalog Models
  • Humanized Immune Checkpoints
    • Single-targeted mice
      • hPD-1
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    • Double-targeted mice
      • hCD3ε/hCD28
      • hPD-1/hPD-L1
      • hPD-1/hLAG3
      • hPD-1/hTIM3
      • hPD-1/hVISTA
      • hPD-1/hCTLA-4
      • hCTLA-4/hLAG3
      • hGITR/Foxp3
      • hGITR/hGITRL
    • Triple-targeted mice
      • PD-1/GITR/GITRL
  • Immunodeficient & Reconstituted
    • Immunodeficient rodents
      • BRGSF mouse
      • SDRG rat
    • With human immune system
      • BRGSF-HIS mouse
      • BRGSF-A2-HIS mouse
  • Humanized Immune Targets
    • T-cell engager mice
      • hCD3ε
      • hCD3ε/hCD28
    • Inflammation & allergy mice
      • hCD4
      • hlgE/hFcεR1
      • hTNF-α
  • Other Mice & Rats
    • PK:PD studies
      • HSA/hFcRn
      • HSA/hFcRn/Rag1-KO
    • Conditional Knockouts
      • Eucomm repository
    • Reporters
      • IL-4-IRES-eGFP
      • Foxp3-IRES-mRFP
      • hGITR/Foxp3
    • Rats
      • GFP reporter
      • Btk Knockout
      • SDRG
  • Cell Lines
    • Humanized
      • MC38-hPD-L1
      • CT26-hPD-L1
    • Knockouts
      • MC38-Pd-l1
      • CT26-Pd-l1
    • Humanized with reporter
      • MC38-hPD-L1-LZ
      • MC38-hPD-L1-hCD47-LZ
      • MC38-hPD-L1-hHER2-LZ
      • CT26-hCD39-LZ
      • CT26-hEpCAM-LZ
      • EL4-hCD20-LZ
      • EL4-hCD19-LZ
Customized Models
  • Customized Mouse Models
    • Knockout mouse models
      • Conditional Knockouts
      • – Tissue-specific Knockouts
      • – Time-dependent Knockouts
      • Constitutive Knockouts
      • Protein function Knockouts
    • Knockin mouse models
      • Humanized Knockins
      • Point mutation Knockins
      • Reporter Knockins
      • Quick KI (Rosa26, Hprt)
      • Conventional Knockins
  • Customized Rat Models
    • Constitutive Knockouts
    • Conditional Knockouts
    • – Tissue-specific Knockouts
    • – Time-dependent Knockouts
    • Point mutations
    • Quick KI (Rosa26)
  • Customized Cell Lines
    • Constitutive Knockouts
    • Inducible Knockdowns
    • Point mutations
    • Reporter Knockins
    • Quick KI (Rosa26)
    • Knockins
Science & Techno
  • Scientific Publications
    • Highlights
      • A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway
    • Papers
      • 2021-23
      • Archives
    • Posters
      • Complementarity of BRGSF-HIS and hVISTA
  • Commmentaries & Case studies
    • Commentaries
      • Human myeloid compartment in BRGSF-HIS
      • Assessing T-cell engagers in vivo
      • Targeting tumor-associated myeloid cells
      • Test T cell engagers: the case of CD28
      • Highly permissive to engraftment
      • NOTUM to prevent colorectal cancer
      • Novel Treatments for Obesity?
      • Tumor grafts in preclinical research
      • Back to the rat
      • Uncoupling Toxicity from Efficacy
      • Degradation Tag Systems
      • Humanized CD3ε: T-cell engagement
      • Targeted Protein Degradation
      • Define “Humanized”: Two Mouse Models Helping...
      • See more...
    • Case studies
      • Myeloid cells: Case on LAIR1
      • Study nerve grafts in rats
      • LDLR rats for atherosclerosis
      • HSA/hFcR/Rag1-KO: A New Xenograft Model
      • Rat models: The case of BMPR2
      • tHis is a reliable model
      • Rat models: The case of CD89
      • Metabolic Disorders - A Case Study on GLP-1R
      • Deciphering HD IL-2 Toxicity in HIS Mice
  • Technologies
    • CRISPR/Cas9 gene editing
      • A nuclease-based genome editing
      • CRISPR/Cas9 patents
    • Homologous recombination
      • A gene targeting technology
      • Typical model creations
    • Site-specific recombination
      • Overview
      • Cre-ERt2: Inducible Cre activity
      • FLEx: Inducible point mutations
      • RMCE: Swapping genes
    • IRES: Internal ribosome entry site
      • Co-expression of several genes
    • TET-on/off
      • On demand gene induction
    • SMASH
      • Drug-inducible protein degradation
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Use of Models
>
Applications for HR Models
>
Models for Translational Medicine
>
Overview

Disease Models for Translational Medicine

By investigating mechanisms underlying human pathologies’ etiology and mechanisms, preclinical models are essential tools to efficiently translating data from the clinic.

Example 1: Cell Deletion Using Suicide Genes
 
Example2: Tissue- and/or Time-Specific Expression of Disease Causal Genes
 
Example 3: Humanization with Human Mutant Genes

Use of Models

Applications for HR Models
  • Humanization of Target Genes
  • Monitoring Biomarker Expression
  • Monitoring Off-Target Effects
  • Labeling for Cell Trafficking
  • Models for Translational Medicine
    • Suicide Genes
    • Disease Causual Genes
    • Human Mutant Genes
  • Tissue-Specific Gene Expression
  • Target Validation & Knockouts
Therapeutic Area
Drug Discovery
Oncology

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Catalog Models
  • Humanized Immune Checkpoints
  • Immunodeficient & Reconstituted Rodents
  • Mice with Humanized Immune Targets
  • T-cell Engager Mice
  • Inflammation & Allergy Mice
  • PK:PD Mice
  • Conditional Knockout Mice
  • Reporter Mice
  • Rats
  • Cell Lines
Customized Models
  • Customized Mouse Models
  • Customized Rat Models
  • Customized Cell Lines
Science & Technology
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  • Case studies
  • Technologies
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About Us
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Applications
  • For Models Created by Knockin
  • For Drug Discovery Programs
  • Therapeutic Areas
  • Syngeneic Models