METTL3 and m⁶A levels are elevated in mouse and human ADPKD samples. Kidney‑specific overexpression of Mettl3 induces tubular cysts; conditional deletion slows cyst growth in three orthologous ADPKD mouse models. Elevated methionine/SAM drive Mettl3 expression and cystogenesis; dietary methionine restriction attenuates disease. METTL3 increases m⁶A and translation of c‑Myc and Avpr2.
Mettl3 overexpression promotes cystogenesis; KO delays cyst growth; methionine/SAM axis regulates METTL3; dietary restriction modulates disease; c‑Myc and Avpr2 regulated via m⁶A
Mettl3^flox/flox conditional knockout mouse (genOway-developed) crossed with kidney-specific Cre drivers in ADPKD backgrounds
ADPKD; renal cystogenesis; RNA methylation; metabolic regulation; dietary therapy; c‑Myc, Avpr2 signaling
Conditional KO with kidney-specific Cre; ADPKD background (e.g., Pkd1, Pkd2); dietary methionine modulation; m⁶A-seq; translatome analysis
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