Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF‐A2 humanized mice resemble those in human samples

Laura Labarthe
CEA-Université Paris-Sud 11
January 1, 2019
J Leukoc Biol
https://pubmed.ncbi.nlm.nih.gov/31378988

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/31378988

Research summary

This study assessed the expression of exhaustion and senescence markers on human T cells reconstituted in BRGSF-A2 humanized mice. The marker profiles, including PD-1, TIGIT, KLRG1, and CD57, showed strong similarity to human T cell populations, particularly in spleen and bone marrow. The model replicates key immunological features of human T cell aging and exhaustion.

Key outcome of the study

Marker expression patterns in reconstituted human T cells mimic those in human donors, validating this model for studying immune exhaustion and evaluating T cell-targeting therapies.

Model

BRGSF-A2 humanized mouse model developed by genOway, using HLA-A2 transgenic BRGSF mice reconstituted with human CD34⁺ hematopoietic stem cells.

TARGET:
CD3E, CD4, CD8A
CD3 epsilon chain, CD4, CD8 alpha

Keywords

Immunotherapy, T cell exhaustion, Senescence, Humanized mouse model, HLA-A2, CD34+ engraftment

Technical specifications

Humanized immune system model, CD34+ HSC engraftment, HLA-A2 transgene, BRGSF background

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genO‑BRGSF-A2-HIS mice possess the most functional reconstituted human immune system. HLA molecules on thymic epithelial cells hinder T-cell cross-reactivity.

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