This study assessed the expression of exhaustion and senescence markers on human T cells reconstituted in BRGSF-A2 humanized mice. The marker profiles, including PD-1, TIGIT, KLRG1, and CD57, showed strong similarity to human T cell populations, particularly in spleen and bone marrow. The model replicates key immunological features of human T cell aging and exhaustion.
Marker expression patterns in reconstituted human T cells mimic those in human donors, validating this model for studying immune exhaustion and evaluating T cell-targeting therapies.
BRGSF-A2 humanized mouse model developed by genOway, using HLA-A2 transgenic BRGSF mice reconstituted with human CD34⁺ hematopoietic stem cells.
Immunotherapy, T cell exhaustion, Senescence, Humanized mouse model, HLA-A2, CD34+ engraftment
Humanized immune system model, CD34+ HSC engraftment, HLA-A2 transgene, BRGSF background
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
