The study investigates the role of MARCHF6 in hepatic lipid homeostasis using conditional loss of Marchf6. MARCHF6 deficiency caused spontaneous hepatic steatosis and major alterations in hepatic lipid metabolism, demonstrating an essential role for this E3 ubiquitin ligase in maintaining liver metabolic homeostasis.
Conditional loss of Marchf6 caused spontaneous hepatosteatosis and altered hepatic lipid metabolism, supporting a central role for MARCHF6 in regulating lipid and sterol homeostasis in the liver.
Conditional loss of Marchf6 caused spontaneous hepatosteatosis and altered hepatic lipid metabolism, supporting a central role for MARCHF6 in regulating lipid and sterol homeostasis in the liver.
Hepatosteatosis, fatty liver disease, hepatic lipid metabolism, cholesterol homeostasis, metabolic disease, ubiquitin proteasome system
Marchf6^flox/flox conditional Knockout, Cre-mediated gene deletion, liver-specific gene inactivation, metabolic phenotyping, liver histology, lipid analysis, gene expression analysis
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