Lung macrophages require TFF2 to drive alveolar type 2‑cell proliferation after sterile injury, helminth infection (Nippostrongylus brasiliensis), or bleomycin exposure. Conditional deletion of Tff2 in myeloid cells (CD11c^Cre Tff2^flox) impaired repair, reduced macrophage Wnt4/Wnt16 expression, and worsened pathology; recombinant Wnt4/Wnt16 rescued proliferation.
Myeloid Tff2 supports AT2 proliferation via Wnt4/Wnt16; loss of Tff2 impairs lung repair; recombinant Wnts restore regeneration
CD11c^Cre; Tff2^flox myeloid‑specific conditional KO mouse — genOway-developed (C57BL/6 background)
Lung tissue repair; epithelial regeneration; macrophage–epithelium crosstalk; Wnt signaling; helminth infection; sterile injury
Conditional knockout; Cre‑loxP (CD11c); lung injury models (bleomycin, helminth); recombinant ligand rescue
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