Target

Gene symbol :  
Psen2
NCBI gene ID :  
19165
Gene full name :  
Presenilin 2
Synonym :  
Presenilin 2

Protein function

Protein name :  
PSEN2
Component of gamma-secretase complex; cleaves APP and Notch receptors.

Expected phenotype

Amyloid processing defects, cognitive changes

Human disease relevance

Associated with familial Alzheimer's disease

Model applications

Alzheimer’s modeling, APP processing

Keywords:

Gamma-secretase, APP, Neurodegeneration

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Psen2

conditional Knockout mouse

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