A finely tuned crosstalk between enteric neurons and muscularis macrophages: evidence from a conditional Knockout mouse model developed by genOway

3 min read
January 14, 2020
cell

Matheis F, Muller PA, Graves CL, Gabanyi I, Kerner ZJ, Costa-Borges D, Ahrends T, Rosenstiel P, Mucida D.
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.
Cell. 2020 Jan.

A recent study, freshly published in Cell by a group of researchers at Rockefeller University, demonstrates that enteric infections cause rapid neuronal loss via the two non-canonical inflammasomes Nlrp6 and Casp11. This was elegantly demonstrated by infecting conditional Knockout mice with an attenuated strain of Salmonella enterica and, subsequently, quantifying the numbers of enteric neurons.

In addition, researchers found that resident macrophages rapidly respond to enteric pathogens by activating the β2-adrenergic receptor (β2-AR) signaling that, in turn, triggers the synthesis of neuroprotective polyamines, thereby limiting neuronal loss. These findings suggest an extremely sophisticated interplay between enteric neurons and macrophages similar to what has been already described for the central nervous system.

Related products

Catalogue product

No items found.

Customized product

Tissue-specific KO mouse

Use tissue- or cell-specific conditional Knockout mouse models to bypass embryonic lethality, compensatory mechanisms, complex phenotypes, etc.

Time-dependent KO mouse

Use an inducible conditional Knockout mouse to age-dependently inactivate your gene, and to enable studies at defined development stages or on age-related diseases.

Other commentaries