Double humanized genO-hCD47/hSIRPα mouse model and MC38 cell line expressing human CD47 for efficacy and safety assessment of anti-CD47/SIRPα-targeting therapies
Humanized mice for anti-CD47/SIRPα-targeting therapies
Background
CD47 is overexpressed on many human tumor cells and interacts with its ligand, the signal-regulating protein alpha (SIRPα), a protein expressed on macrophages and dendritic cells, to induce a “don’t eat me” signal. CD47 and its interaction with phagocytes is therefore a promising therapeutic target to treat cancer. Herein, we describe a double humanized genO-hCD47/hSIRPα model for efficacy, safety assessment and biodistribution of human CD47/SIRPα-targeting therapies in immunocompetent mice. The double humanized genO-hCD47/hSIRPα mouse model (genO-hCD47/hSIRPα) was generated by intercrossing genO-hCD47 and genO-hSIRPα mice models whose designs enable expression of all human isoforms at physiological levels.
Scientific excellence
From model design to experimental results
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Collaborative approach
Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions
Robust validation data on catalog models
Generated with biopharma partners and in-house
Innovative technologies
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Easy access to models
Models with certified health status from professional breeders in US and Europe