This study describes the development of a transgenic mouse model expressing human CEACAM6 in the small intestine, allowing for colonization by adherent-invasive Escherichia coli (AIEC), a pathobiont linked to Crohn’s disease. The model serves as a platform to study host-pathogen interactions and evaluate microbiota-targeting therapies.
Expression of human CEACAM6 in the ileum enables enhanced colonization by AIEC, providing a physiologically relevant in vivo model for testing anti-AIEC strategies in Crohn’s disease.
Vill-hCC6 Knockin mouse model developed by genOway, expressing human CEACAM6 under the villin promoter. The transgene was inserted into the murine Hprt locus using homologous recombination in 129P2/OlaHsd ES cells.
Crohn’s disease, AIEC infection, Intestinal inflammation, Host-pathogen interaction, Microbiota therapeutics
Knockin model, Hprt locus targeting, Villin promoter, Human CEACAM6 expression, AIEC colonization
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
