An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor

Li J
March 1, 2025
Gynecol Oncol
https://pubmed.ncbi.nlm.nih.gov/40221170

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/40221170

Research summary

This study presents an inducible mouse model carrying the FOXL2 C134W mutation, mimicking the mutation found in nearly all human adult-type granulosa cell tumors (AGCTs). Induction of this mutation in granulosa cells results in tumor formation that resembles human AGCT histologically and molecularly.

Key outcome of the study

Inducible expression of the FOXL2 C134W mutation in granulosa cells leads to ovarian tumors phenotypically and molecularly similar to human AGCTs, providing a highly relevant model for studying pathogenesis and testing therapies.

Mouse model

FOXL2 C134W inducible Knockin mouse model developed by genOway, using the FLEx system for Cre-dependent inversion and expression of the point-mutated Foxl2 gene specifically in granulosa cells.

TARGET:
Foxl2
Forkhead box L2

Keywords

Ovarian cancer, Granulosa cell tumor, FOXL2 mutation, Preclinical tumor model

Technical specifications

Inducible point mutation model, FLEx technology, Cre-lox system, Endogenous locus targeting, Tissue-specific activation

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