This study presents an inducible mouse model carrying the FOXL2 C134W mutation, mimicking the mutation found in nearly all human adult-type granulosa cell tumors (AGCTs). Induction of this mutation in granulosa cells results in tumor formation that resembles human AGCT histologically and molecularly.
Inducible expression of the FOXL2 C134W mutation in granulosa cells leads to ovarian tumors phenotypically and molecularly similar to human AGCTs, providing a highly relevant model for studying pathogenesis and testing therapies.
FOXL2 C134W inducible Knockin mouse model developed by genOway, using the FLEx system for Cre-dependent inversion and expression of the point-mutated Foxl2 gene specifically in granulosa cells.
Ovarian cancer, Granulosa cell tumor, FOXL2 mutation, Preclinical tumor model
Inducible point mutation model, FLEx technology, Cre-lox system, Endogenous locus targeting, Tissue-specific activation
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
