Fatehullah et al. engineered a Claudin18‑IRES‑CreERT2 Knockin allele to drive conditional dysregulation of Wnt, RTK, and Trp53 pathways in gastric epithelium, inducing chromosomal‑instable, metastatic gastric cancer. Orthotopic transplantation and in vivo ablation of tumour-resident Lgr5⁺ stem-like cells demonstrated their necessity for tumour initiation, maintenance, and metastasis.
Conditional mutation in gastric epithelium produces metastatic gastric cancer; Lgr5⁺ cells initiate and sustain tumour burden; ablation prevents metastasis and progression
Claudin18‑IRES‑CreERT2 Knockin mouse, used with conditional alleles of Smad4, Pten, and often reporter Lgr5‑DTR or lineage-tracing alleles; genOway‑developed (C57BL/6)
Gastric cancer stem cells; tumour initiation; metastatic progression; preclinical models; organoid transplantation; conditional dysregulation
Claudin18‑IRES‑CreERT2 Knockin in gastric epithelium; conditional floxed alleles (Smad4, Pten); Lgr5 lineage tracing and ablation (e.g., DTR); orthotopic transplantation of cancer organoids; CreERT2 induction; metastasis assays
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