This study shows that disrupting the talin‑1 actin‑binding site (ABS3) via the KVK/DDD point mutation impairs focal adhesion maturation, cell migration, and leads to embryonic lethality in mice.
ABS3 mutation causes embryonic lethality, disrupted actin organization, and defective cell–ECM adhesion, establishing the critical role of talin-mediated actin binding in morphogenesis.
Tln1^KVK/DDD point mutation Knockin mouse model developed by genOway on C57BL/6 background, allowing assessment of talin‑actin linkage during embryogenesis and in primary fibroblasts.
Developmental biology, Cell adhesion, Mechanobiology, Embryogenesis
Knockin, Point mutation (KVK>DDD), Actin-binding disruption, C57BL/6
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
