The study demonstrates that FFA4 (GPR120) signals intracrinally at lipid droplet membranes to suppress basal lipolysis in adipocytes. Using a Ffar4 conditional Knockout mouse, they showed that adipocyte‑specific deletion of FFA4 disrupts its localization to lipid droplets, enhances lipolysis, and increases fatty acid release. This intracrine role was independent of classical GPCR surface signaling.
Adipocyte‑specific deletion of FFA4 increases lipolysis and fatty acid efflux. FFA4 localizes to lipid droplets and functions independently of surface receptor signaling; identifies novel intracrine GPCR function
Ffar4^flox/flox conditional Knockout mouse, crossed with adipocyte-specific Cre lines — genOway-developed, C57BL/6 background
Lipolysis regulation, adipose tissue metabolism, GPCR intracellular signaling, metabolic disease, fatty acid homeostasis
Conditional Knockout of Ffar4 (GPCR), adipocyte-specific Cre expression, lipid droplet isolation, live-cell and ex vivo adipose imaging, metabolic assays of fatty acid release
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