This study explores how Agpat5 in AgRP neurons regulates the counterregulatory response to hypoglycemia. Conditional deletion of Agpat5 in AgRP neurons impaired glucose-sensing neuronal activity and reduced glucagon secretion in response to insulin-induced hypoglycemia. This reveals Agpat5’s key role in glucose homeostasis through central neuronal pathways.
Agpat5 deletion in AgRP neurons disrupts the neuronal response to hypoglycemia and blunts glucagon secretion, emphasizing its role in neuroendocrine regulation of blood glucose.
Conditional Agpat5 Knockout mouse model developed by genOway, using Flex technology for Cre-dependent gene inactivation. The model includes an IRES-linked reporter allowing for traceable expression.
Hypoglycemia, Glucagon secretion, AgRP neurons, Neuroendocrinology, Glucose regulation
Conditional Knockout, Flex technology, IRES reporter, Cre-dependent inactivation, Neuron-specific targeting
From model design to experimental results
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