The study shows that androgen receptor (AR) signaling represses IKBKE via an enhancer RNA (IKBKE‑e). In prostate cancer, combined irradiation plus AR pathway inhibition activates innate immune signaling. Ablation of IKBKE‑e or combinatorial treatment enhanced antitumor immunity in mice. Experiments were performed in genO‑BRGSF‑HIS humanized mice implanted with human prostate cancer cells to assess immune infiltration and tumor control upon treatment.
Targeting IKBKE enhancer RNA derepressed IKBKE expression and enhanced innate immune activation. Combined antiandrogen plus irradiation improved T cell infiltration and anticancer immunity. AR and HDAC2 were identified as intrinsic immune suppressors acting through IKBKE‑e.
genO‑BRGSF‑HIS humanized mouse — genOway‑developed, CD34+ HSC‑engrafted immuno‑oncology model
Immuno‑oncology, innate immune signaling in cancer, prostate cancer immunotherapy, AR signaling modulation, humanized mouse model for tumor immunity
CD34+ HSC engraftment in genO‑BRGSF‑HIS mice, tumor implantation with human prostate cancer cells, IR plus AR pathway inhibition, IKBKE‑e targeting, immune cell profiling by flow cytometry, antitumor efficacy readouts
From model design to experimental results
Featured in 600+ scientific articles
Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions
Generated with biopharma partners and in-house
and guaranteed freedom to operate
Models with certified health status from professional breeders in US and Europe
