This study characterizes the immune composition and tumor response in genO-BRGSF-HIS humanized mice, reconstituted with human CD34⁺ stem cells. Functional human immune subsets including myeloid cells, dendritic cells, NK cells, γδ T cells, and T cells are recruited into tumors in a tumor-type and tumor-size dependent manner. The model is validated for testing immunotherapies including T-cell engagers in an in vivo humanized context.
Tumor-infiltrating human myeloid and lymphoid cells show functional activation. Immune cell recruitment patterns vary based on tumor model and burden. The model supports in vivo testing of immunotherapies and exhibits long-term immune cell persistence without major toxicity.
genO-BRGSF-HIS humanized mouse, reconstituted with human CD34⁺ HSCs — genOway-developed
Humanized mouse, immuno-oncology, tumor immune infiltration, functional myeloid and lymphoid cell evaluation, T-cell engager testing
CD34⁺ HSC engraftment, exogenous Flt3L to support myeloid lineage, subcutaneous tumor xenografts using human cell lines, flow cytometry of immune compartments, cytokine and activation marker profiling, immunotherapy readouts in vivo
From model design to experimental results
Featured in 600+ scientific articles
Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions
Generated with biopharma partners and in-house
and guaranteed freedom to operate
Models with certified health status from professional breeders in US and Europe
