Immunodeficient mouse and rat strain portfolio

BRGSF: Immunodeficient Mouse Models (→ read more)

Our immunodeficient mouse model portfolio is based on the proprietary state-of-the-art BRGS mouse model.

Compared to traditional immunodeficient strains, such as NOD-SCID and NSG, the BRGSF mouse represents the most immunodeficient model generated to date, with defect of both the murine lymphoid and myeloid compartments, and thus represents a strongly adapted animal model for xenograft of human tumor and/or immune system.

The portfolio consists of the following strains:

• BRGS (BALB/c Rag2^tm1Fwa Il2rg^tm1Cgn Sirpa^NOD)
• BRGSF (BALB/c Rag2^tm1Fwa Il2rg^tm1Cgn Sirpa^NOD Flt3^tm1lrl)
• BRGSF-A2 (genetically humanized for HLA-A2^HHD–Tg(HLA-A/H2-D/B2M)^1Bpe)

SDRG: Immunodeficient Rat Model (→ read more)

Compared to the traditional immunodeficient nude rats, which lack T cells but maintain a normal repertoire of all other immune cells, including B and NK cells, the SDRG model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1^-/-Il2rγ^-/-), resulting in a B, T and NK cell deficiency.

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