Immunodeficient rats represent powerful tools to investigate the pathobiology of B cell disorders such as leukemias and lymphomas, as well as lymphoid compartment development.

They are valid alternatives to immunodeficient mice since, e.g., the liquid nature of malignancies like B cell lymphoma make downstream analysis quite challenging due to small blood volumes of mice.

Compared to the traditional immunodeficient nude rats, which lack T cells but maintain a normal repertoire of all other immune cells, including B and NK cells, the SDRG model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1-/- Il2rγ-/-), resulting in a B, T and NK cell deficiency.

Applications

The SDRG rat represents a valid preclinical model to study:

  • Lymphoid compartment development
  • B cell malignancies (e.g., leukemias, lymphomas)
  • Xenografts
  • Inflammatory disorders
  • Infectious diseases

Validation

Related resources and publications

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