Applications of the genO‑HSA/hFcRn-RAG1KO mouse model

Useful applications for researchers working on different biomedical fields, such as immuno-oncology and autoimmunity:

  • Assess the efficacy of optimized therapeutics such as Fc-engineered antibodies, constructs fused to HSA, HSA- and/or FcRn-binding proteins or small molecules in a human tumor model, while avoiding the development of anti-drug antibodies (ADA)
  • Assess pharmacokinetic and pharmacodynamic (PK/PD) features, including biodistribution and binding affinity
  • Screen compounds based on extended half-life

Features

  • Murine Rag1 is invalidated, resulting in deficient T- and B-cell development
  • Efficient tumor growth upon injection of human cancer cells
  • Physiological HSA and hFcRn expression profile and regulation
  • Higher physiological affinity of human serum albumin for human FcRn
  • No expression of the murine target genes

Clients

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑HSA/hFcRn-RAG1KO

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