Our double-humanized serum albumin/neonatal Fc receptor mouse model (HSA/hFcRn) maintains an autologous receptor-ligand interaction and can mimic the physiological drug clearance in humans.

This upgraded, immunocompromised Rag1-/- system (HSA/hFcRn-Rag1-/-) allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

Applications

  • Efficacy assessment of drug conjugates, antibodies (e.g., T-cell engagers), and any albumin- and FcRn-binding compounds
  • Accurate and predictive PK/PD studies of albumin- and FcRn-binding compounds

HSA/hFcRn-Rag1-/- model features

  • Murine Rag1 is invalidated, leading to a deficiency in T- and B-celldevelopment
  • Physiological HSA and hFcRn expression profile and regulation in a mouse system, as they are both controlled by their respective endogenous mouse promoters (murine albumin and FcRn expression is abolished)
  • Efficient tumor growth upon human cancer cells injection

Validation

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HSA/hFcRn-Rag1-KO

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Mouse
HSA
PK/PD

HSA/hFcRn

Use this double humanized HSA/hFcRn mouse model for accurate and predictive PK/PD studies of albumin- and FcRn-binding compounds.-/- version of our HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

Immunocompromised double-humanized HSA/hFcRn-Rag1-KO mouse model

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