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Design of the genO-GFP rat strain
The genO-GFP rat line has been developed by inserting, within the rat Rosa26 locus, a CAG-eGFP using CRISPR/Cas9 technology.
Applications
This new genO-GFP rat strain is suitable for organ and tissue transplantation, and therefore useful for many biomedical fields including development, toxicology and orthotopic transplantation.
You can generate various eGFP rat cell lines from organs to be used for multiple purposes, e.g., to study genome-editing technologies in rat models.
Features
- Ubiquitous eGFP expression from Rosa26 locus
- One transgene CAG-eGFP copy located in the coding-free, intronic region of Rosa26 locus
- eGFP is strongly expressed in all main organs and tissues
- eGFP expression at embryonic stage
- No change in productivity index (fertility, litter size, etc.)
- Sprague Dawley genetic background
Clients
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