Bruton’s tyrosine kinase (Btk) is a cytoplasmic enzyme encoded by the human BTK gene that plays a crucial role in B cell development, survival, proliferation and differentiation. Btk defect leads to X-linked agammaglobulinemia (XLA), a rare genetic disorder that strongly reduces the immune system, thereby affecting the ability of the organism to fight effectively against infections. Btk is also an important target for the development of innovative therapies (i.e., Btk inhibitors) for patients suffering hematologic malignancies such as chronic lymphocytic leukemia (CLL), and mantle cell lymphoma (MCL).

Applications

As rats more accurately reflect human physiology than mice, genOway has developed the first preclinical Btk Knockout rat model (Btk KO) to help scientists study a broad spectrum of medical fields, including:

  • Immunology
  • B cell malignancies (e.g., diffuse large B-cell lymphoma, chronic lymphocytic leukemia)
  • Autoimmune diseases with aberrant B cell responses (e.g., rheumatoid arthritis, systemic lupus erythematosus)
  • Hematology (e.g., hemostasis, thrombosis)
  • Toxicology
  • Screening of novel Btk inhibitors for treatment of several hematologic cancers and autoimmune diseases
  • Oncology (e.g., pancreatic cancer, breast cancer)

Model features

  • Lack of Btk protein expression
  • B-cell developmental defects (i.e., decreased number of peripheral B cells, defects in B-cell maturation and activation)
  • Sprague Dawley outbred genetic background

Validation

Related ressources et publications

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
No results
No results

Discover related products to

Btk rat

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Rats
Reporter
GFP

GFP rat

The GFP rat is suitable for organ & tissue transplantations and used in many biomedical fields (development, toxicology, orthotopic transplantation).

Rats
Immunodeficient
SDRG

SDRG

The immunodeficient SDRG rat model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1-/- Il2rγ-/-), resulting in a B, T, and NK cell deficiency.

Brutons tyrosine kinase Knockout rat model

Get in touch about

Let us know how we can help

In order to provide you the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please tick the checkbox below.

From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.