Immunodeficient SDRG Rat Model

Rat Model Catalog

Immunodeficient rats represent powerful tools to investigate the pathobiology of B cell disorders such as leukemias and lymphomas, as well as lymphoid compartment development.

They are valid alternatives to immunodeficient mice since, e.g., the liquid nature of malignancies like B cell lymphoma make downstream analysis quite challenging due to small blood volumes of mice.

Compared to the traditional immunodeficient nude rats, which lack T cells but maintain a normal repertoire of all other immune cells, including B and NK cells, the SDRG model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1-/- Il2rγ-/-), resulting in a B, T and NK cell deficiency.


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The SDRG rat represents a valid preclinical model to study:

  • Lymphoid compartment development
  • B cell malignancies (e.g., leukemias, lymphomas)
  • Xenografts
  • Inflammatory disorders
  • Infectious diseases

Model features

  • Sprague Dawley genetic background
  • Lack of Rag1 and IL-2Rγ protein expression



Model validation

SDRG rats display no T, B and NK and NKT cells

SDRG rat model validation

Hemocytometer and flow cytometry count of T, B, NK, NKT and myeloid cells in SDRG and wild-type Sprague Dawley rats. SDRG rats display a significantly reduced number of T and B cells (upper graphics) and NK cells (lower graphics) compared to wild-type Sprague Dawley rats. Flow cytometry analyses of T, B, NK, NKT and myeloid cells (CD3+ TCRαβ+, CD3- CD45R+, CD3- TCRαβ- CD335+ CD161+, CD3+ TCRαβ- CD335+ CD161+, CD3- CD45R- CD161- respectively) in blood and spleen.

* For more validation data please contact us.


Further reading


Ready to be shipped to your lab

  • Cohorts available upon request
  • SPF certification and worldwide delivery by professional breeders
  • Models provided with FTO on patent-protected technologies used for model generation