Immunodeficient SDRG Rat Model
Immunodeficient rats represent powerful tools to investigate the pathobiology of B cell disorders such as leukemias and lymphomas, as well as lymphoid compartment development.
They are valid alternatives to immunodeficient mice since, e.g., the liquid nature of malignancies like B cell lymphoma make downstream analysis quite challenging due to small blood volumes of mice.
Compared to the traditional immunodeficient nude rats, which lack T cells but maintain a normal repertoire of all other immune cells, including B and NK cells, the SDRG model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1-/- Il2rγ-/-), resulting in a B, T and NK cell deficiency.
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The SDRG rat represents a valid preclinical model to study:
- Lymphoid compartment development
- B cell malignancies (e.g., leukemias, lymphomas)
- Inflammatory disorders
- Infectious diseases
- Sprague Dawley genetic background
- Lack of Rag1 and IL-2Rγ protein expression
SDRG rats display no T, B and NK and NKT cells
Hemocytometer and flow cytometry count of T, B, NK, NKT and myeloid cells in SDRG and wild-type Sprague Dawley rats. SDRG rats display a significantly reduced number of T and B cells (upper graphics) and NK cells (lower graphics) compared to wild-type Sprague Dawley rats. Flow cytometry analyses of T, B, NK, NKT and myeloid cells (CD3+ TCRαβ+, CD3- CD45R+, CD3- TCRαβ- CD335+ CD161+, CD3+ TCRαβ- CD335+ CD161+, CD3- CD45R- CD161- respectively) in blood and spleen.
* For more validation data please contact us.
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Ready to be shipped to your lab
- Cohorts available upon request
- SPF certification and worldwide delivery by professional breeders
- Models provided with FTO on patent-protected technologies used for model generation