Relevant preclinical models to test T cell engagers: the case of CD28
Despite its ability to produce cytokines upon CD28 stimulation, the hCD28 mouse model is not recommended for safety and toxicity studies, due to its genetic design, as it might not trigger a cytokine release syndrome (CRS) with the same intensity than that in humans. Of note, genOway’s reconstituted mouse model BRGSF-HIS has proved most relevant to recapitulate CRS in a preclinical model.
The CD28 example perfectly illustrates the central importance of a relevant preclinical research model. Indeed, the choice of the most appropriate model entirely depends on the application. This is why genOway has developed and offers a set of catalog models fit for a variety of applications, including optimized models for T-cell-targeting bispecific antibodies and combination therapies.
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