Design of the hCD3ε mouse

The humanized CD3ε mouse model was developed to express the human epitope of the CD3ε chain, which is recognized by T-cell engagers (clone SP34). The rest of the extracellular domain is murine to preserve the amino acids involved in the interaction with CD3γ and CD3δ.

Similarly, the transmembrane domains and the intracellular domains are murine to enable salt bridges’ interaction, interaction with the CD3ζ, and the signaling into mouse cells.

Features of the hCD3ε mouse

  • Extracellular CD3ε N-terminal epitope is humanized
  • Conserved interaction with CD3γ, CD3δ and CD3ζ interactions
  • Fully functional mouse immune system

Validation

Related resources and publications

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