Design of the hCD28 mouse

The humanized CD28 model, developed by Knockin at the mouse CD28 locus, expresses a chimeric CD28 with a human extracellular and murine transmembrane and intracellular domains. The design also gives access to CD28 conditional Knockout mice.

hCD28 features

  • The CD28 extracellular domain is entirely humanized
  • Physiological regulation and expression pattern of the human CD28
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity

Validation

Related ressources et publications

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