A4galt-CreERT2 mouse line

Inducible Cre driver for epithelial and glycolipid-associated A4galt-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
A4galt
Target system:
Epithelial tissues, metabolism
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659523

Scientific relevance & applications  

A4GALT encodes alpha 1,4-galactosyltransferase, an enzyme involved in glycosphingolipid biosynthesis and cell surface antigen formation. Its expression is associated with epithelial tissues and cellular processes related to membrane composition and glycosylation. The A4galt-CreERT2 mouse line enables inducible, temporal control of genetic recombination in A4galt-expressing cells following tamoxifen administration. This model is suitable for studying glycosylation pathways, membrane biology, and epithelial tissue function.

A4galt-CreERT2 mouse line

mouse line

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