Atf4-CreERT2 mouse line

Inducible Cre driver for stress-responsive Atf4-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Atf4
Target system:
Ubiquitous, stress response pathways
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122924

Scientific relevance & applications  

ATF4 is a transcription factor activated under cellular stress conditions, including amino acid deprivation and endoplasmic reticulum stress. It regulates genes involved in metabolism, stress adaptation, and apoptosis across multiple tissues. The Atf4-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Atf4-expressing cells following tamoxifen administration. This model is suitable for studying stress response pathways, metabolism, and cellular adaptation mechanisms.

Atf4-CreERT2 mouse line

mouse line

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