Cga-CreERT2 mouse line

Inducible Cre driver for endocrine Cga-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Cga
Target system:
Endocrine system, pituitary
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122673

Scientific relevance & applications  

CGA encodes the common alpha subunit of glycoprotein hormones such as TSH, LH, and FSH, and is expressed in endocrine cells of the anterior pituitary. It plays a central role in hormonal regulation and endocrine signaling. The Cga-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Cga-expressing endocrine cells following tamoxifen administration. This model is suitable for studying pituitary function, hormonal regulation, and endocrine disorders.

Cga-CreERT2 mouse line

mouse line

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